Although Cleveland can match the best home mark in NBA history at 40-1 on Wednesday night, All-Stars LeBron James and Mo Williams along with veterans Zydrunas Ilgauskas and Joe Smith will not play against the free-falling Philadelphia 76ers.

The Cavaliers (66-15) clinched the top seed in the Eastern Conference with a 102-92 victory at Philadelphia (40-41) on Friday, but still needed two wins to ensure they'd have the league's best record and home-court advantage should they meet the Los Angeles Lakers in the NBA finals.

Cleveland throttled defending champion Boston by 31 points at home Sunday to improve to 39-1 at Quicken Loans Arena, then wrapped up the NBA's best record with a 117-109 win at Indiana the following night.

"It's one step, however, it's a big step," said James, who finished with 37 points - the 14th time he's scored at least that many this season. "When you consider all the great teams, all the great players, all the great coaches and all the great systems that are in the NBA, for us to finish with the best record is a tremendous feat. And that is something the franchise should be proud of."

James and most of the Cavs' top players will get to savor it from the bench Wednesday, as coach Mike Brown said it was an "easy" decision to rest his stars and keep them healthy before the playoffs. Cleveland can tie the 1985-86 Boston Celtics for the best home mark in history.

"We are where we are no matter what," Brown said following the Cavs' morning shootaround. "Obviously, we can tie the record. That's the only thing we gain out of playing our guys. Other than that, we could have an injury, and for me that would be the most devastating thing you could possibly think of this late in the game."

The depleted Cavs lineup, though, will be facing a Philadelphia team that's desperately in need of a win. The 76ers have lost six straight and are trying to avoid a first-round matchup with the second-seeded Celtics.

The Sixers locked up a playoff berth with a 95-90 win over Detroit on April 4 and had a chance to earn the fourth or fifth seed. Now, they'll get a matchup with the Celtics unless they beat Cleveland and Toronto wins at Chicago.

Philadelphia had a chance to get back on track Tuesday against a Celtics team that was missing Kevin Garnett and Ray Allen and had nothing to play for. Instead, the Sixers blew a double-digit lead in the third quarter and lost 100-98 despite the return of starter Thaddeus Young.

"We should have won the game," said guard Andre Iguodala, who had a team-high 25 points. "They used a second unit for the majority of the game."

The Sixers are 0-4 against the Celtics and 0-3 against the Magic.

Young had missed the past seven games with a sprained right ankle but had 18 points in his return to the lineup. Prior to the game in which he suffered the injury, Young averaged 23.6 in his previous seven contests.

Young is averaging 8.0 points in two losses to Cleveland.

The Cavaliers have won all three meetings with the Sixers this season behind 28.0 points per game from James, and Cleveland has taken five straight in the series overall.

Philadelphia is 6-14 in the second game of back-to-backs.